Which genetic disorder is characterized by the clogging of the respiratory and digestive systems with mucus?

Cystic Fibrosis is the correct answer because it is a genetic disorder caused by mutations in the CFTR gene, which leads to the production of thick and sticky mucus that can clog the airways in the lungs and obstruct the pancreas in the digestive system. This buildup of mucus can result in serious respiratory infections and digestive problems, making it a distinctive characteristic of the disease.

In contrast, Sickle Cell Anemia involves abnormal hemoglobin causing red blood cells to become rigid and sickle-shaped, leading to different health complications primarily related to blood flow. Tay-Sachs Disease is a neurodegenerative disorder that leads to the destruction of nerve cells in the brain and spinal cord, not mucus production. Huntington's Disease is a genetic disorder that causes progressive degeneration of nerve cells in the brain, leading to movement, cognitive, and psychiatric issues. Each of these disorders has its unique pathophysiology and symptoms that differentiate them from Cystic Fibrosis.