Which genetic disorder is characterized by clogging of the respiratory and digestive systems with mucus?

Cystic fibrosis (CF) is characterized by the buildup of thick, sticky mucus in various organs, particularly the lungs and digestive system. This condition is caused by mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which plays a crucial role in the production of sweat, digestive fluids, and mucus. The faulty protein results in glands producing mucus that is unusually thick and viscous, leading to blockages in the airways, making breathing difficult and increasing susceptibility to infections in the lungs.

In the digestive system, this thick mucus can obstruct the pancreas, preventing the release of enzymes necessary for digestion, which can result in malnutrition and poor growth.

In contrast, sickle cell anemia is a blood disorder characterized by the production of abnormal hemoglobin, leading to misshapen red blood cells, while Huntington's disease is a neurodegenerative disorder that affects movement and cognitive functions. Phenylketonuria (PKU) is a metabolic disorder caused by the deficiency of the enzyme phenylalanine hydroxylase, leading to an inability to metabolize the amino acid phenylalanine. Each of these other conditions has distinct pathophysiological mechanisms and does not involve the characteristic mucus buildup seen in cyst